Bioanalytical methods

DRUG

MATRIX

TECHNIQUE

2-PYRIDYLACETIC ACID

plasma

LC-MS/MS

5-AMINOSALICYLIC ACID (MESALAZINE)~

hep. plasma

LC-MS/MS

~ N-Acetyl-5-Aminosalicylic Acid

5-FLUOROCYTOSINE

serum

HPLC-UV

6-THIOGUANINE

plasma

LC-MS/MS

ACETYLSALICYLIC ACID

hep. plasma

HPLC-UV

ALPRAZOLAM

plasma

HPLC-UV

AMINOACIDS

plasma

HPLC-FL

AMITRIPTYLINE

plasma

LC-MS/MS

AMOXICILLIN

plasma

HPLC-UV, FL

ARIPIPRAZOLE

plasma

LC-MS/MS

ATENOLOL

whole blood

HPLC-FL

ATORVASTATIN~

plasma

LC-MS/MS

~ 2-OH-Atorvastatin

AZITHROMYCIN

plasma, pig plasma

LC-MS/MS

BICALUTAMIDE

hep. plasma

LC-MS/MS

BROMAZEPAM

plasma

HPLC-UV

BUMETANIDE

hep. plasma

HPLC-FL

CAFFEINE

plasma

HPLC-UV

CARBAMAZEPIN

serum

HPLC-UV

CARVEDILOL

plasma

LC-MS/MS

CEFACLOR

plasma

HPLC-UV

CEFADROXIL

plasma

HPLC-UV

CEFIXIME

plasma

HPLC-UV

CEFPODOXIME

plasma

HPLC-UV

CEFUROXIME

plasma

HPLC-UV

CETIRIZINE

hep. plasma

HPLC-UV

CILOSTAZOL

plasma

LC-MS/MS

CIMETIDINE

plasma

HPLC-UV

CIPROFLOXACIN

plasma

HPLC-FL

CITALOPRAM

plasma

HPLC-FL

CLINDAMYCIN

ox. plasma

HPLC-UV

CLOXACILIN

serum

HPLC-FL

CYCLOSPORIN A

whole blood

HPLC-UV

DEFALZACORT~

plasma

LC-MS/MS

~ 21-desacetyldeflazacort

DEXAMETHASONE

hep. plasma

LC-MS/MS

DEXTRORPHAN

plasma

HPLC-UV

DIAZEPAM

plasma

LC-MS/MS

DICLOFENAC~

plasma, urine

HPLC-UV, EC

~ 4-OH-Diclofenac

urine

HPLC-EC

DIFLUNISAL

plasma

HPLC-UV

DILTIAZEM~

plasma

HPLC-UV

~ Desacetyldiltiazem

~ N-Demethyldiltiazem

DIPYRIDAMOLE

plasma

LC-MS/MS

DONEPEZIL

hep. plasma

LC-MS/MS

DOXEPIN

plasma

HPLC-UV

DOXYCYCLINE

hep. plasma

HPLC-UV

EZETIMIBE (free)

hep. plasma

LC-MS/MS

EZETIMIBE (total)

hep. plasma

LC-MS/MS

FENOFIBRIC ACID

ox. plasma

HPLC-UV

FLOBUFEN + metab.

plasma

HPLC-UV

FLUCONAZOLE

plasma

HPLC-UV

FLURBIPROFEN

plasma

HPLC-UV

FUROSEMIDE

plasma

HPLC-FL

GLIBENCLAMIDE

hep. plasma

LC-MS/MS

HYDRALAZINE

plasma

HPLC-FL

HYDROCORTISONE

hep. plasma

LC-MS/MS

HYDROXYCHLOROQUINE

wh. blood

LC-MS/MS

HYDROCHLOROTHIAZIDE

plasma

LC-MS/MS

HYDROXYZINE

plasma

LC-MS/MS

HYPERICIN~

plasma

HPLC-FL

~ Pseudohypericin

IBUPROFEN (racemate)

plasma

LC-MS/MS

IBUPROFEN (chiral)

plasma

HPLC-UV, FL

IMATINIB

plasma

LC-MS/MS

INDAPAMIDE

plasma

HPLC-UV

IRBESARTAN

plasma

LC-MS/MS

ISOSORBIDE-5-Mononitrate

hep. plasma

LC-MS/MS

KETOPROFEN

plasma / wh. blood

HPLC-UV

LAMOTRIGINE

plasma

LC-MS

LEVETIRACETAM

plasma

HPLC-UV

LEVOFLOXACIN

plasma

HPLC-FL

LOSARTAN~

plasma

LC-MS/MS

~ Losartan carboxylic acid

MEBENDAZOLE

plasma

HPLC-UV

MEFENAMIC ACID

plasma

HPLC-UV

MELOXICAM

plasma

HPLC-UV

MEMANTINE

plasma

LC-MS/MS

METHOTREXATE

plasma

LC-MS/MS

METOLAZONE

plasma

LC-MS/MS

METOPROLOL

plasma

HPLC-FL

MIDODRINE

plasma

LC-MS/MS

MIGLUSTAT

plasma

LC-MS/MS

MODAFINIL

hep. plasma

LC-MS/MS

MONTELUKAST

plasma

LC-MS

MOXIFLOXACIN

plasma

HPLC-FL

MYSOLINE

serum

HPLC-UV

N-ACETYLPROCAINAMID

serum

HPLC-UV

NALTREXONE~

hep. plasma

LC-MS/MS

~ 6-beta-naltrexol

NAPROXEN

plasma

HPLC-UV

NICARDIPINE

plasma

LC-MS/MS

NIMESULIDE~

plasma

HPLC-UV

~ 4-hydroxynimesulide

NORTRIPTYLINE

serum

HPLC-UV

OCTREOTIDE

plasma, rat hep. plasma

LC-MS/MS

OLANZAPINE

plasma

LC-MS/MS

OXAZEPAM

plasma

LC-MS/MS

OXCARBAZEPINE~

plasma

LC-MS/MS

~ 10-hydroxycarbazepine

OXYCODONE

plasma

LC-MS/MS

PARACETAMOL

plasma

LC-MS/MS

PAROXETINE

plasma

LC-MS/MS

PENICILLIN V

plasma

HPLC-UV

PENTOBARBITAL

serum

HPLC-UV

PHENOBARBITAL

serum

HPLC-UV

PHENYTOIN

serum

HPLC-UV

PINDOLOL

plasma

HPLC-FL

PIOGLITAZONE~

plasma

LC-MS/MS

~ Hydroxypioglitazone

PIROXICAM

hep. plasma

HPLC-UV

PROCAINAMID

plasma

HPLC-UV

PROPRANOLOL~

plasma, serum

HPLC-FL

~ 4-OH-Propranolol

QUETIAPINE

plasma

LC-MS/MS

QUINIDINE

serum

HPLC-UV

RASAGILINE

serum

LC-MS/MS

RIBAVIRIN

LC-MS/MS

RISEDRONATE

plasma

LC-MS/MS

RISPERIDONE~

plasma, dog plasma

LC-MS/MS

~ Hydroxyrisperidone

rabbit, rat plasma

RISPERIDONE

rabbit plasma, rabbit serum

LC-MS/MS

RIVASTIGMINE

plasma

LC-MS/MS

ROSIGLITAZONE

plasma

LC-MS/MS

SALICYLIC ACID

plasma, hep. plasma

HPLC-FL, UV

SERTRALINE

plasma

LC-MS/MS

SIBUTRAMINE~

plasma

LC-MS/MS

~ Desmethylsibutramine

~ Didesmethylsibutramine

SILDENAFIL~

hep. plasma

LC-MS/MS

SIMVASTATIN~

plasma

LC-MS/MS

~ Simvastatin Hydroxy Acid

SOLIFENACIN

plasma

LC-MS/MS

SULFAMETHOXAZOLE

plasma

HPLC-UV

SUMATRIPTAN

plasma

HPLC-EC

TELMISARTAN

plasma

LC-MS/MS

TERBINAFINE

plasma

HPLC-UV

TETRABENAZINE~

plasma

LC-MS/MS

~ alpha-dihydrotetrabenazine

plasma

LC-MS/MS

THEOPHYLLINE

plasma

HPLC-UV

THIOCOLCHICOSIDE~

plasma

LC-MS/MS

~ 3-O-glucuronidated aglycone

TIBOLONE~

plasma

LC-MS/MS

~ 3alpha-hydroxytibolone

~ 3beta-hydroxytibolone

TICLOPIDINE

plasma

HPLC-UV

TOPIRAMATE

plasma

LC-MS/MS

TOLTERODINE~

plasma

LC-MS/MS

~ 5-hydroxymethyl tolterodine

TRAMADOL~

plasma

LC-MS/MS

~ O-Desmethyltramadol

TRAZODONE

plasma

HPLC-FL

TRIAZOLAM

plasma

HPLC-UV

TRIMETHOPRIM

plasma

HPLC-UV

URSODEOXYCHOLIC ACID~

plasma

LC-MS/MS

~ glycoursodeoxycholic acid

~ tauroursodeoxycholic acid

VALSARTAN

plasma

LC-MS/MS

VALPROIC ACID

plasma

HPLC-UV

VERAPAMIL~

plasma

HPLC-FL

~ Norverapamil

plasma

VITAMIN C

plasma

UPLC-MS

ZOLPIDEM

plasma

HPLC-FL